Author: Carvalho, Miguel F.; Gill, Davinder
Title: Rotavirus vaccine efficacy: current status and areas for improvement Document date: 2018_9_19
ID: 14a5861f_27
Snippet: Improving vaccine targeting to M cells with existing or novel ligands (including small molecules) using better M cell culture systems 68 and vaccine encapsulation strategies 65, 67 would likely raise immunization efficiency in developing nations. In that regard, old and potentially new ligands could be validated in vitro using translational fusions or conjugations to pertinent (delivery) systems such as lactic acid bacteria, subunit vaccines, syn.....
Document: Improving vaccine targeting to M cells with existing or novel ligands (including small molecules) using better M cell culture systems 68 and vaccine encapsulation strategies 65, 67 would likely raise immunization efficiency in developing nations. In that regard, old and potentially new ligands could be validated in vitro using translational fusions or conjugations to pertinent (delivery) systems such as lactic acid bacteria, subunit vaccines, synthetic nanoparticles and VP4 (VP5*/VP8*) Rotavirus spike head protein. These findings would be extended to in vivo assays using appropriate preclinical models, with the most promising leads being evaluated in clinical trials.
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