Author: Labib, Bisant A; Minhas, Bhawanjot K; Chigbu, DeGaulle I
Title: Management of Adenoviral Keratoconjunctivitis: Challenges and Solutions Document date: 2020_3_17
ID: 6ehvyoug_23_1
Snippet: ofovir 1% lowered the frequency of severe corneal opacities in patients with adenoviral keratoconjunctivitis. 64, 106 Narrow therapeutic index when used topically; high doses for greater than one week associated with rare cases of lacrimal canalicular blockade in rabbit models. 107 Ganciclovir 3% ganciclovir reduced HAdV 5 replication and pathogenesis in animal models. 108 Ganciclovir is efficacious against HAdV types that cause EKC. 46 Ganciclov.....
Document: ofovir 1% lowered the frequency of severe corneal opacities in patients with adenoviral keratoconjunctivitis. 64, 106 Narrow therapeutic index when used topically; high doses for greater than one week associated with rare cases of lacrimal canalicular blockade in rabbit models. 107 Ganciclovir 3% ganciclovir reduced HAdV 5 replication and pathogenesis in animal models. 108 Ganciclovir is efficacious against HAdV types that cause EKC. 46 Ganciclovir ophthalmic gel treatment prevents complications in adenoviral ocular infection. 109 Transient blur following instillation, eye irritation, punctate keratitis, conjunctival hyperemia. 108 Brincidofovir Brincidofovir has antiviral activity against adenoviruses. 55 DovePress of these issues, more research is required to determine a standard protocol (Table 3) .
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