Author: Martin, Baptiste; Coutard, Bruno; Guez, Théo; Paesen, Guido C; Canard, Bruno; Debart, Françoise; Vasseur, Jean-Jacques; Grimes, Jonathan M; Decroly, Etienne
Title: The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure Document date: 2018_9_6
ID: 243u68j8_5
Snippet: In this study, we produced and purified the C-terminal region of SUDV L protein and characterized its enzymatic activities. We showed that this domain has a dual MTase activity. We demonstrated that SUDV MTase predominantly carries out an unconventional, cap-independent 2'Omethylation targeting adenosine residues within capped and uncapped RNAs, in addition to the canonical capdependent N7 and 2'O methylations......
Document: In this study, we produced and purified the C-terminal region of SUDV L protein and characterized its enzymatic activities. We showed that this domain has a dual MTase activity. We demonstrated that SUDV MTase predominantly carries out an unconventional, cap-independent 2'Omethylation targeting adenosine residues within capped and uncapped RNAs, in addition to the canonical capdependent N7 and 2'O methylations.
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