Title: The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre- Golgi compartment Document date: 1992_8_2
ID: 04455ffs_43
Snippet: To obtain further information on the properties of the tubular El-containing membranes, we carried out experiments with agents known to differentially affect ER and Golgi membranes. For example, the Golgi complex is dispersed upon treatment with microtubule-depolymerizing agents such as nocodazole (49) and BFA (17, 32) whereas the RER is unaffected. In contrast, thapsigargin, a specific inhibitor of ER Ca 2. ATPase which causes a rapid depletion .....
Document: To obtain further information on the properties of the tubular El-containing membranes, we carried out experiments with agents known to differentially affect ER and Golgi membranes. For example, the Golgi complex is dispersed upon treatment with microtubule-depolymerizing agents such as nocodazole (49) and BFA (17, 32) whereas the RER is unaffected. In contrast, thapsigargin, a specific inhibitor of ER Ca 2. ATPase which causes a rapid depletion of ER Ca 2+ stores via an inositol triphosphate-independent mechanism (58), results in vesiculation of ER membranes and subsequent secretion of luminal ER proteins while the Golgi is unaffected (8, 25) .
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