Author: Tromas, Nicolas; Zwart, Mark P.; Forment, Javier; Elena, Santiago F.
Title: Shrinkage of Genome Size in a Plant RNA Virus upon Transfer of an Essential Viral Gene into the Host Genome Document date: 2014_2_20
ID: 5fejitls_42
Snippet: Thus, we conclude that all mutations except E1206D increase accumulation of TEV-ÃNIb early in infection and that this effect was even stronger for double mutations. High levels of early accumulation are likely to occur for a virus variant that expands rapidly, and therefore suggest an increase in the within-host fitness of the evolved lineages. The mutations in the 6K1/CI proteolytic site were not observed in the wild-type virus, suggesting that.....
Document: Thus, we conclude that all mutations except E1206D increase accumulation of TEV-ÃNIb early in infection and that this effect was even stronger for double mutations. High levels of early accumulation are likely to occur for a virus variant that expands rapidly, and therefore suggest an increase in the within-host fitness of the evolved lineages. The mutations in the 6K1/CI proteolytic site were not observed in the wild-type virus, suggesting that this is an instance of adaptive evolution contingent upon deletion of NIb.
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