Selected article for: "IFN expression and NF κB activation"
Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity
  • Document date: 2016_1_11
    • ID: 42d77vxf_38
    Snippet: Nrdp1 is an E3 that promotes IFN-I expression at the expense of proinflammatory cytokines. TBK1 polyubiquitination by Nrdp1 activates TBK1 in TRIF-mediated IFN-I expression, which simultaneously K48-polyubiquitinates and down-regulates MyD88-mediated NF-κB activation . Conversely, the ubiquitin-editing enzyme A20 inhibits ubiquitin-mediated activation of TRAF6, inhibiting NF-κB activation via the TLR and NLR cascades, as well as TBK1, inhibitin.....
    Document: Nrdp1 is an E3 that promotes IFN-I expression at the expense of proinflammatory cytokines. TBK1 polyubiquitination by Nrdp1 activates TBK1 in TRIF-mediated IFN-I expression, which simultaneously K48-polyubiquitinates and down-regulates MyD88-mediated NF-κB activation . Conversely, the ubiquitin-editing enzyme A20 inhibits ubiquitin-mediated activation of TRAF6, inhibiting NF-κB activation via the TLR and NLR cascades, as well as TBK1, inhibiting IFN-I expression Turer et al., 2008; Parvatiyar et al., 2010) . Additional avenues of signaling cross-talk include Smurf1 and Smurf2, which degrade MAVS and inhibit IFN-I activation. Smurf1 and Smurf2 also degrade MyD88, inhibiting TLR-mediated NF-κB activation (Lee et al., 2011) .

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