Author: Heaton, Steven M.; Borg, Natalie A.; Dixit, Vishva M.
Title: Ubiquitin in the activation and attenuation of innate antiviral immunity Document date: 2016_1_11
ID: 42d77vxf_9
Snippet: The unfurled RIG-I CARDs undergo tetramerization upon K63-linked polyubiquitination or unanchored polyubiquitin chain association (Peisley et al., 2014) . These modifications drive mitochondrial accumulation of RIG-I, promoting CARD-CARD interac- (1) Ubiquitin (Ub) expresses as an inactive polyprotein, encoded by the UBB and UBC genes. DUbs cleave this polyprotein into monomers that are activated by the E1-activating enzyme, involving the energy-.....
Document: The unfurled RIG-I CARDs undergo tetramerization upon K63-linked polyubiquitination or unanchored polyubiquitin chain association (Peisley et al., 2014) . These modifications drive mitochondrial accumulation of RIG-I, promoting CARD-CARD interac- (1) Ubiquitin (Ub) expresses as an inactive polyprotein, encoded by the UBB and UBC genes. DUbs cleave this polyprotein into monomers that are activated by the E1-activating enzyme, involving the energy-dependent adenylation of the ubiquitin C-terminal glycine. The ubiquitin-adenylate intermediate (dashed line) converts into a covalent thioester bond (solid line). (2) Ubiquitin transfers to the active site cysteine residue of an E2-conjugating enzyme.
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