Author: Kim, Sung-Kwon; Cornberg, Markus; Wang, Xiaoting Z.; Chen, Hong D.; Selin, Liisa K.; Welsh, Raymond M.
Title: Private specificities of CD8 T cell responses control patterns of heterologous immunity Document date: 2005_2_21
ID: 55gi6gyx_1
Snippet: Variations in the pathogenesis of viral infections can sometimes be attributed to the infection history of a host, where exposure to unrelated pathogens may unexpectedly contribute either to protective immunity or to enhanced immunopathology (1). This heterologous immunity has now been demonstrated in several murine models of infection, where T cells specific to previously encountered viruses participate in the immune response to viruses subseque.....
Document: Variations in the pathogenesis of viral infections can sometimes be attributed to the infection history of a host, where exposure to unrelated pathogens may unexpectedly contribute either to protective immunity or to enhanced immunopathology (1). This heterologous immunity has now been demonstrated in several murine models of infection, where T cells specific to previously encountered viruses participate in the immune response to viruses subsequently encountered (2) (3) (4) . Recent work showing human T cell cross-reactivity between influenza virus and hepatitis C virus (5) , between influenza virus and Epstein-Barr virus (6) , between human papilloma virus and coronavirus (7) , and between different strains of dengue virus (8) argues that similar issues of heterologous immunity should be examined in human infections.
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