Author: Lundegaard, Claus; Lund, Ole; Kesmir, Can; Brunak, Søren; Nielsen, Morten
Title: Modeling the adaptive immune system: predictions and simulations Document date: 2007_12_15
ID: 5m269nzi_41
Snippet: With respect to TAP-independent transport and cleavage of peptides, the most established model is especially connected to the most abundant HLA supertype (A2) and is related to the signal peptides and the processing of such . Prediction of potential signal peptides that can be transported by Sec61 can be made with tools for prediction of signal peptides, and some of these will also predict the signal peptidase cleavage site (Bendtsen et al., 2004.....
Document: With respect to TAP-independent transport and cleavage of peptides, the most established model is especially connected to the most abundant HLA supertype (A2) and is related to the signal peptides and the processing of such . Prediction of potential signal peptides that can be transported by Sec61 can be made with tools for prediction of signal peptides, and some of these will also predict the signal peptidase cleavage site (Bendtsen et al., 2004; Kall et al., 2004; Zhang and Henzel, 2004) , but the value in the context of CD8þ T-cell epitope predictions remains to be elucidated.
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