Selected article for: "damage response and dna damage"
Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants
  • Document date: 2014_4_10
    • ID: 1nm1tbig_17
    Snippet: Recent studies have suggested that physical adjuvants may be beneficial for DNA vaccines. Electrical current as an adjuvant has been tested in mice [55] , rhesus macaques [56, 57] , and humans [58 & ]. The results suggest that electroporation alone is as effective as DNA-encoded adjuvants, although side-effects were higher in electroporation groups [58 & ]. Electroporation almost certainly acts by increasing uptake of vaccine DNA into cells and t.....
    Document: Recent studies have suggested that physical adjuvants may be beneficial for DNA vaccines. Electrical current as an adjuvant has been tested in mice [55] , rhesus macaques [56, 57] , and humans [58 & ]. The results suggest that electroporation alone is as effective as DNA-encoded adjuvants, although side-effects were higher in electroporation groups [58 & ]. Electroporation almost certainly acts by increasing uptake of vaccine DNA into cells and through minor tissue damage that stimulates damage-associated PRRs that recruit an inflammatory response. Further testing will be needed to determine whether electroporation can be implemented so as to reduce side-effects yet remain effective.

    Search related documents:
    Co phrase search for related documents
    • damage associate and tissue damage: 1, 2, 3
    • dna encode and vaccine dna: 1, 2, 3
    • dna vaccine and effective remain: 1, 2, 3, 4
    • dna vaccine and inflammatory response: 1
    • dna vaccine and recent study: 1, 2, 3
    • dna vaccine and rhesus macaque: 1, 2
    • dna vaccine and vaccine dna: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • effect reduce and inflammatory response: 1, 2, 3, 4, 5
    • effect reduce and recent study: 1
    • effect reduce and tissue damage: 1, 2, 3
    • effective remain and inflammatory response: 1
    • effective remain and recent study: 1, 2
    • effective remain and rhesus macaque: 1, 2
    • effective remain and tissue damage: 1
    • inflammatory response and recent study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • inflammatory response and rhesus macaque: 1, 2, 3
    • inflammatory response and tissue damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • recent study and tissue damage: 1, 2, 3, 4