Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_17
Snippet: Recent studies have suggested that physical adjuvants may be beneficial for DNA vaccines. Electrical current as an adjuvant has been tested in mice [55] , rhesus macaques [56, 57] , and humans [58 & ]. The results suggest that electroporation alone is as effective as DNA-encoded adjuvants, although side-effects were higher in electroporation groups [58 & ]. Electroporation almost certainly acts by increasing uptake of vaccine DNA into cells and t.....
Document: Recent studies have suggested that physical adjuvants may be beneficial for DNA vaccines. Electrical current as an adjuvant has been tested in mice [55] , rhesus macaques [56, 57] , and humans [58 & ]. The results suggest that electroporation alone is as effective as DNA-encoded adjuvants, although side-effects were higher in electroporation groups [58 & ]. Electroporation almost certainly acts by increasing uptake of vaccine DNA into cells and through minor tissue damage that stimulates damage-associated PRRs that recruit an inflammatory response. Further testing will be needed to determine whether electroporation can be implemented so as to reduce side-effects yet remain effective.
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