Author: Robinson, Lary A; Smith, Prudence; SenGupta, Dhruba J; Prentice, Jennifer L; Sandin, Ramon L
Title: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates Document date: 2013_12_21
ID: 3unap1o9_113
Snippet: For peer review only -http://bmjopen.bmj.com/site/about/guidelines.xhtml 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 .....
Document: For peer review only -http://bmjopen.bmj.com/site/about/guidelines.xhtml 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 The fundamental pathologic abnormality in the disease is the formation of non-caseating epitheliod granulomas, which usually confine poorly soluble foreign material that simply cannot be removed by a single phagocytic cell. The key feature in sarcoidosis is activated CD4+ T cells which differentiate into type 1 helper T cells (Th1), secreting interleukin-2 and interferon-γ, augmenting macrophage TNF-α, and amplifying the local cellular immune response. 3, 4 This granulomatous inflammation interferes with local tissue homeostasis leading to organ impairment.
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