Author: Robinson, Lary A; Smith, Prudence; SenGupta, Dhruba J; Prentice, Jennifer L; Sandin, Ramon L
Title: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates Document date: 2013_12_21
ID: 3unap1o9_64
Snippet: • Additionally, the number of lymph nodes positive for bacterial DNA may be significantly underestimated because of the tendency of the formalin-fixation and paraffin embedding process to breakdown prokaryotic DNA. The fundamental pathologic abnormality in the disease is the formation of non-caseating epitheliod granulomas, which usually confine poorly soluble foreign material that simply cannot be removed by a single phagocytic cell. The key f.....
Document: • Additionally, the number of lymph nodes positive for bacterial DNA may be significantly underestimated because of the tendency of the formalin-fixation and paraffin embedding process to breakdown prokaryotic DNA. The fundamental pathologic abnormality in the disease is the formation of non-caseating epitheliod granulomas, which usually confine poorly soluble foreign material that simply cannot be removed by a single phagocytic cell. The key feature in sarcoidosis is activated CD4+ T cells which differentiate into type 1 helper T cells (Th1), secreting interleukin-2 and interferon-γ, augmenting macrophage TNF-α, and amplifying the local cellular immune response. 3, 4 This granulomatous inflammation interferes with local tissue homeostasis leading to organ impairment.
Search related documents:
Co phrase search for related documents- bacterial dna and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- bacterial dna and lymph node: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cellular immune response and disease pathologic abnormality: 1, 2
- cellular immune response and foreign material: 1, 2
- cellular immune response and fundamental disease pathologic abnormality: 1, 2
- cellular immune response and granulomatous inflammation: 1, 2
- cellular immune response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cellular immune response and key feature: 1, 2
- cellular immune response and local cellular immune response: 1, 2, 3, 4, 5
- cellular immune response and lymph node: 1, 2, 3, 4
- cellular immune response and non caseating epitheliod: 1, 2
- cellular immune response and organ impairment: 1, 2
- disease pathologic abnormality and fundamental disease pathologic abnormality: 1, 2
- disease pathologic abnormality and granulomatous inflammation: 1, 2
- disease pathologic abnormality and immune response: 1, 2
- disease pathologic abnormality and key feature: 1, 2
- disease pathologic abnormality and local cellular immune response: 1, 2
- disease pathologic abnormality and non caseating epitheliod: 1, 2
- disease pathologic abnormality and organ impairment: 1, 2
Co phrase search for related documents, hyperlinks ordered by date