Selected article for: "cell line and TK ÏÖϪ cell"
Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition
  • Document date: 1999_7_19
    • ID: 1vabzhs5_19
    Snippet: Recognition of Endogenously Synthesized Antigen. The ability of HCV core 178-induced CTLs to recognize endogenously synthesized CYP2A6 antigen was studied using the AHH-1 TK ϩրϪ cell line transfected with CYP2A6 (h2A3), and cells transfected with the unrelated CYP2D6 (h2D6) as target cells in 4-and 8-h cytotoxicity assays. Killing of CYP2A6-transfected cells by CTL lines from donor 2 was higher than lysis of the parental cell line AHH-1 TK Ï©Ö.....
    Document: Recognition of Endogenously Synthesized Antigen. The ability of HCV core 178-induced CTLs to recognize endogenously synthesized CYP2A6 antigen was studied using the AHH-1 TK ϩրϪ cell line transfected with CYP2A6 (h2A3), and cells transfected with the unrelated CYP2D6 (h2D6) as target cells in 4-and 8-h cytotoxicity assays. Killing of CYP2A6-transfected cells by CTL lines from donor 2 was higher than lysis of the parental cell line AHH-1 TK ϩրϪ or control cells transfected with CYP2D6 (Fig. 4) , suggesting that naturally processed CYP2A6 8-17 peptide is generated by the proteolytic machinery and presented on the HLA-A2 molecule.

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