Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_19
Snippet: Recognition of Endogenously Synthesized Antigen. The ability of HCV core 178-induced CTLs to recognize endogenously synthesized CYP2A6 antigen was studied using the AHH-1 TK ϩրϪ cell line transfected with CYP2A6 (h2A3), and cells transfected with the unrelated CYP2D6 (h2D6) as target cells in 4-and 8-h cytotoxicity assays. Killing of CYP2A6-transfected cells by CTL lines from donor 2 was higher than lysis of the parental cell line AHH-1 TK Ï©Ö.....
Document: Recognition of Endogenously Synthesized Antigen. The ability of HCV core 178-induced CTLs to recognize endogenously synthesized CYP2A6 antigen was studied using the AHH-1 TK ϩրϪ cell line transfected with CYP2A6 (h2A3), and cells transfected with the unrelated CYP2D6 (h2D6) as target cells in 4-and 8-h cytotoxicity assays. Killing of CYP2A6-transfected cells by CTL lines from donor 2 was higher than lysis of the parental cell line AHH-1 TK ϩրϪ or control cells transfected with CYP2D6 (Fig. 4) , suggesting that naturally processed CYP2A6 8-17 peptide is generated by the proteolytic machinery and presented on the HLA-A2 molecule.
Search related documents:
Co phrase search for related documents- cell kill and cytotoxicity assay: 1, 2
- cell line and control cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- cell line and CTL line: 1
- cell line and cytotoxicity assay: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell line and HCV core: 1
- cell line and parental cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cell line and target cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44
- control cell and cytotoxicity assay: 1, 2, 3, 4
- control cell and target cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cytotoxicity assay and HCV core: 1
- cytotoxicity assay and target cell: 1, 2, 3, 4, 5, 6, 7
- cytotoxicity assay target cell and target cell: 1
- HCV core and target cell: 1
- HCV core ctl and target cell: 1
- parental cell line and target cell: 1
Co phrase search for related documents, hyperlinks ordered by date