Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_22
Snippet: The induction of self-reactive CD8 Ï© CTLs by a viral epitope is compatible with molecular mimicry (resemblance of pathogen and host antigens), a mechanism that has been described mainly at the level of antibodies and CD4 Ï© T cells (16) (17) (18) . Molecular mimicry at the level of T cells has been implicated in human autoimmune diseases such as multiple sclerosis (19, 20) , rheumatoid arthritis (21) , and myocarditis (22) , as well as in herpes.....
Document: The induction of self-reactive CD8 Ï© CTLs by a viral epitope is compatible with molecular mimicry (resemblance of pathogen and host antigens), a mechanism that has been described mainly at the level of antibodies and CD4 Ï© T cells (16) (17) (18) . Molecular mimicry at the level of T cells has been implicated in human autoimmune diseases such as multiple sclerosis (19, 20) , rheumatoid arthritis (21) , and myocarditis (22) , as well as in herpes stromal keratitis (23) . A recent study also describes cross-reactivity of CD8 Ï© T cells specific for a myelin-derived peptide with a Saccharomyces cerevisiae peptide (24) . In this case, cross-reactive CTLs could only be induced with the self-peptide and not with the Saccharomyces antigen.
Search related documents:
Co phrase search for related documents- cross reactive ctl and Ï© ctl: 1
- cross reactive ctl and molecular mimicry: 1
- cross reactive ctl and self peptide: 1
- host antigen and human autoimmune: 1, 2, 3, 4
- host antigen and molecular mimicry: 1, 2
- host antigen pathogen and human autoimmune: 1
- host antigen pathogen and molecular mimicry: 1
- human autoimmune and molecular mimicry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- human autoimmune and multiple sclerosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- human autoimmune disease and molecular mimicry: 1
- human autoimmune disease and multiple sclerosis: 1, 2, 3, 4
- Ï© ctl and multiple sclerosis: 1
- Ï© ctl and self peptide: 1
- molecular mimicry and multiple sclerosis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- molecular mimicry and self peptide: 1
- multiple sclerosis and recent study: 1, 2, 3, 4, 5, 6, 7, 8
- multiple sclerosis and self peptide: 1
Co phrase search for related documents, hyperlinks ordered by date