Selected article for: "group II cov and II cov"
Author: Janice Oh, Hsueh-Ling; Ken-En Gan, Samuel; Bertoletti, Antonio; Tan, Yee-Joo
Title: Understanding the T cell immune response in SARS coronavirus infection
  • Document date: 2012_9_5
    • ID: 5uoepd0r_2
    Snippet: Coronaviruses are a diverse group of large, enveloped positivestranded RNA viruses in the order Nilovirales, family Coronaviridae, and genus Coronavirus. Typically, they cause respiratory and enteric diseases in humans and animals. Using the open reading frame (ORF) 1a sequences, SARS-CoV was categorized as a subgroup of the group II coronaviruses. 9 The 30 kb poly-adenylated positive-stranded RNA genome 10, 11 has an genomic organization typical.....
    Document: Coronaviruses are a diverse group of large, enveloped positivestranded RNA viruses in the order Nilovirales, family Coronaviridae, and genus Coronavirus. Typically, they cause respiratory and enteric diseases in humans and animals. Using the open reading frame (ORF) 1a sequences, SARS-CoV was categorized as a subgroup of the group II coronaviruses. 9 The 30 kb poly-adenylated positive-stranded RNA genome 10, 11 has an genomic organization typical of a coronavirus where the first two ORFs (1a and 1b) encode the viral replicase that requires processing by the viral cysteine proteinases to yield the functional membrane-bound replicase complex and a group of 16 non-structural proteins (NSP). 12 Although some functions of these NSPs have been investigated and known, there are many others that still require further characterization (reviewed by Cheng et al. 13 ).

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