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Author: Ahn, Jin Young; Sohn, Yujin; Lee, Su Hwan; Cho, Yunsuk; Hyun, Jong Hoon; Baek, Yae Jee; Jeong, Su Jin; Kim, Jung Ho; Ku, Nam Su; Yeom, Joon-Sup; Roh, Juhye; Ahn, Mi Young; Chin, Bum Sik; Kim, Young Sam; Lee, Hyukmin; Yong, Dongeun; Kim, Hyun Ok; Kim, Sinyoung; Choi, Jun Yong
Title: Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea
  • Document date: 2020_4_6
  • ID: 1uwir5b8_9
    Snippet: A 67-year-old woman with a medical history of hypertension developed fever and myalgia and diagnosed as COVID-19 via SARS-CoV-2 rRT-PCR on March 6. The next day, she was admitted to a local public medical center and received hydroxychloroquine 400 mg once daily and lopinavir/ritonavir 400 mg/100 mg twice daily with empirical antibiotics. However, on day 3, she was transferred to the tertiary-care hospital due to increased oxygen demand and worsen.....
    Document: A 67-year-old woman with a medical history of hypertension developed fever and myalgia and diagnosed as COVID-19 via SARS-CoV-2 rRT-PCR on March 6. The next day, she was admitted to a local public medical center and received hydroxychloroquine 400 mg once daily and lopinavir/ritonavir 400 mg/100 mg twice daily with empirical antibiotics. However, on day 3, she was transferred to the tertiary-care hospital due to increased oxygen demand and worsening infiltrative shadows in the left lower lung. At that time, her oxygen saturation checked 93% on 4 L/min oxygen flow via nasal cannula with a respiratory rate of 24 times per She received high flow oxygen therapy but bilateral infiltration and oxygenation were deteriorated, so intubation and mechanical ventilator care started on day 4. Intravenous methylprednisolone (0.5 mg/kg/day daily) was also added. She had sustained high fever with rapidly increasing CRP (314 mg/L), WBC (21.79 × 10 3 /µL), and persistent lymphopenia (0.5 × 10 3 /µL). PaO 2 /FiO 2 fell to 76, consistent with severe ARDS. After applying for the prone position according to the management of ARDS with the use of steroids, chest images and the oxygen demand began to be improved.

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