Selected article for: "cell cell and high concentration"
Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation
  • Document date: 2017_6_9
    • ID: 7q2wkwrf_46
    Snippet: Unlike free subunit antigens, nanoparticle vaccines present a high concentration of antigens on their surfaces. A nanoparticle can be surface functionalized with up to hundreds of antigens, effectively emulating the antigen display on viral surfaces [179, 180] . The multivalent antigen display on nanoparticles enhances antibody responses by efficiently cross-linking BCRs, activating complement, and facilitating antibody binding. These factors pla.....
    Document: Unlike free subunit antigens, nanoparticle vaccines present a high concentration of antigens on their surfaces. A nanoparticle can be surface functionalized with up to hundreds of antigens, effectively emulating the antigen display on viral surfaces [179, 180] . The multivalent antigen display on nanoparticles enhances antibody responses by efficiently cross-linking BCRs, activating complement, and facilitating antibody binding. These factors play synergistic roles in promoting B cell differentiation and stimulating DC-mediated T cell priming.

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