Author: Nicastri, Emanuele; Petrosillo, Nicola; Bartoli, Tommaso Ascoli; Lepore, Luciana; Mondi, Annalisa; Palmieri, Fabrizio; D’Offizi, Gianpiero; Marchioni, Luisa; Murachelli, Silvia; Ippolito, Giuseppe; Antinori, Andrea
Title: National Institute for the Infectious Diseases “L. Spallanzani”, IRCCS. Recommendations for COVID-19 clinical management Document date: 2020_3_16
ID: 4r0t3q7j_56
Snippet: Although the optimal dose and schedule of TCZ for treatment of CRS is not known, the intended posology is 8 mg/kg intravenously (maximum 800 mg/dose) infused over an hour. Additional administration(s) are evaluated on the basis of patient's response to TCZ 8-12 hours apart, in case of: -Absence/poor clinical improvement or clinical worsening and/or -Failure in reduction of 50% baseline Creactive protein (a reliable surrogate marker of IL-6) or fa.....
Document: Although the optimal dose and schedule of TCZ for treatment of CRS is not known, the intended posology is 8 mg/kg intravenously (maximum 800 mg/dose) infused over an hour. Additional administration(s) are evaluated on the basis of patient's response to TCZ 8-12 hours apart, in case of: -Absence/poor clinical improvement or clinical worsening and/or -Failure in reduction of 50% baseline Creactive protein (a reliable surrogate marker of IL-6) or failure in normalization and/or -Failure in reduction in D-dimer, fibrinogen or ferritin levels. Dosage adjustment is required in relation to blood parameters of liver function and blood count according to the indications specified in the patient package insert.
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