Selected article for: "low concentration and lung damage"
Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial
  • Document date: 2019_5_18
    • ID: 19ueli6e_53
    Snippet: We could not detect LTA in plasma nor its direct inflammatory response via TLR2. LTA cell wall components should bind TLR2 and induce the release of a broad range of pro-inflammatory cytokines leading to neutrophil-mediated lung damage, and, with that, morbidity and mortality. 31, 32 Most likely, an inhibitory effect of human plasma contributes to the low immune response in these patients. In addition, with a median number of only one infected lu.....
    Document: We could not detect LTA in plasma nor its direct inflammatory response via TLR2. LTA cell wall components should bind TLR2 and induce the release of a broad range of pro-inflammatory cytokines leading to neutrophil-mediated lung damage, and, with that, morbidity and mortality. 31, 32 Most likely, an inhibitory effect of human plasma contributes to the low immune response in these patients. In addition, with a median number of only one infected lung lobe, representing relatively limited pneumococcal load, the LTA plasma concentration could be too low to mount a response via TLR2 in vitro (see the Supplementary data), but may nonetheless have an effect in vivo.

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