Author: Fu, Yu; Lee, Inhan; Lee, Yong Sun; Bao, Xiaoyong
Title: Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Document date: 2015_12_31
ID: 0b08jyjs_23
Snippet: Although tRNA metabolism is essential for all human cells, a number of neurological disorders are caused by defects in tRNA metabolism and tRNA processing enzymes. ANG mutants possessing reduced RNase activity were implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease [54] . A subset of ALSassociated ANG mutants was also found in Parkinson's disease patients [55] . Administration of recombinant A.....
Document: Although tRNA metabolism is essential for all human cells, a number of neurological disorders are caused by defects in tRNA metabolism and tRNA processing enzymes. ANG mutants possessing reduced RNase activity were implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease [54] . A subset of ALSassociated ANG mutants was also found in Parkinson's disease patients [55] . Administration of recombinant ANG to cultured neurons protects them from stress-induced apoptosis and promotes the lifespan and motor function of SOD1 (G93A) mice, a laboratory ALS model.
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