Author: Ma, Yuanmei; Zhang, Yu; Liang, Xueya; Lou, Fangfei; Oglesbee, Michael; Krakowka, Steven; Li, Jianrong
Title: Origin, Evolution, and Virulence of Porcine Deltacoronaviruses in the United States Document date: 2015_3_10
ID: 6o7j5k9n_21
Snippet: We reproduced the PdCV-associated disease in conventional piglets. All four piglets inoculated with 10 6 PFU of PdCV MI developed sudden-onset, severe, and watery diarrhea (scores of 3) at day 1 p.i. The PdCV MI strain caused more severe clinical signs in conventional piglets than in Gn piglets at the same inoculation dose. Piglets were monitored through day 21 p.i. in order to define the duration of diarrhea and viral shedding in infected piglet.....
Document: We reproduced the PdCV-associated disease in conventional piglets. All four piglets inoculated with 10 6 PFU of PdCV MI developed sudden-onset, severe, and watery diarrhea (scores of 3) at day 1 p.i. The PdCV MI strain caused more severe clinical signs in conventional piglets than in Gn piglets at the same inoculation dose. Piglets were monitored through day 21 p.i. in order to define the duration of diarrhea and viral shedding in infected piglets. The diarrhea persisted for 7 to 10 days, and all four piglets were recovered from disease on day 10 p.i. These piglets lost approximately 10 to 15% of body weight on day 10 p.i. and started to gain weight after recovery from the disease.
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