Selected article for: "specificity sensitivity and threshold value"
Author: Srivastava, Sukrit; Kamthania, Mohit; Singh, Soni; Saxena, Ajay K; Sharma, Nishi
Title: Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
  • Document date: 2018_11_21
    • ID: 33h22ikl_54
    Snippet: IFn-γ-inducing epitope prediction IFN-γ is involved in both adaptive and innate immune responses. It stimulates macrophages and natural killer cells. IFN-γ-inducing 15-mer peptide epitopes were predicted from (Table S9 and Figure 7C and G). The AlgPred analysis of CTL and HTL MEVs revealed that both MEVs are nonallergens with the score of −0.95415008 and −0.8647714, respectively, with sensitivity and specificity of 88.87% and 81.86%, respe.....
    Document: IFn-γ-inducing epitope prediction IFN-γ is involved in both adaptive and innate immune responses. It stimulates macrophages and natural killer cells. IFN-γ-inducing 15-mer peptide epitopes were predicted from (Table S9 and Figure 7C and G). The AlgPred analysis of CTL and HTL MEVs revealed that both MEVs are nonallergens with the score of −0.95415008 and −0.8647714, respectively, with sensitivity and specificity of 88.87% and 81.86%, respectively, while the default threshold value was −0.4. The VaxiJen analysis indicated both MEVs to be probable ANTIGENS with prediction score of 0.5302 and 0.5097 for CTL MEVs and HTL MEVs, respectively, while the default threshold value was 0.4 for viral proteins. Hence, both MEVs are predicted to be nonallergic and potentially antigenic in nature.

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