Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus Document date: 2015_12_15
ID: 6bx2nrui_13
Snippet: To determine whether the accumulation of viral RNA derived from the drug-susceptible and drug-resistant genomes mirrored that of infectious virus, the yield of total RNA was determined by qRT-PCR and the proportion of each genome was quantified (Fig. 1) . As with virus, more total RNA accumulated with increasing amounts of total input virus for both MK-0608-resistant alleles ( Fig. 4B and C) . This shows that the genetic dominance of the MK-0608-.....
Document: To determine whether the accumulation of viral RNA derived from the drug-susceptible and drug-resistant genomes mirrored that of infectious virus, the yield of total RNA was determined by qRT-PCR and the proportion of each genome was quantified (Fig. 1) . As with virus, more total RNA accumulated with increasing amounts of total input virus for both MK-0608-resistant alleles ( Fig. 4B and C) . This shows that the genetic dominance of the MK-0608-resistant viruses is due to the rescue of wild-type RNA synthesis.
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