Author: Mateo, Roberto; Nagamine, Claude M.; Kirkegaard, Karla
Title: Suppression of Drug Resistance in Dengue Virus Document date: 2015_12_15
ID: 6bx2nrui_18
Snippet: Dengue virus grows primarily in monocytes, macrophages, and dendritic cells of infected humans and mice (19) (20) (21) . With intravenous inoculations such as those performed here, virus travels directly to the spleen, where it primarily infects macrophages of the marginal zone (19, 20) . Upon infection by the natural intradermal route, on the other hand, dendritic cells present in the periphery become infected before migrating to the spleen (Fig.....
Document: Dengue virus grows primarily in monocytes, macrophages, and dendritic cells of infected humans and mice (19) (20) (21) . With intravenous inoculations such as those performed here, virus travels directly to the spleen, where it primarily infects macrophages of the marginal zone (19, 20) . Upon infection by the natural intradermal route, on the other hand, dendritic cells present in the periphery become infected before migrating to the spleen (Fig. 6) . In either case, in lymph nodes or the spleen, the virus replicates and spreads locally to nearby cells, including red pulp macrophages in the spleen, before dissemination to the bloodstream.
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