Title: Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway Document date: 1995_10_1
ID: 7oklz2ch_32
Snippet: Introduction of the two COOH-terminal phenylalanine residues in absence of the lysines showed an unexpected increase in endo H resistance (Fig. 6, line 8) reflecting comparable rates of transport as shown for L53T4R2AI0 and CD4 (Fig. 4) . The phenylalanines suppress the targeting mediated by the RSQQE determinant. Comparison of a mutant with one lysine changed to serine, and the phenylalanines substituted by alanines (KSAA) to mutants with phenyl.....
Document: Introduction of the two COOH-terminal phenylalanine residues in absence of the lysines showed an unexpected increase in endo H resistance (Fig. 6, line 8) reflecting comparable rates of transport as shown for L53T4R2AI0 and CD4 (Fig. 4) . The phenylalanines suppress the targeting mediated by the RSQQE determinant. Comparison of a mutant with one lysine changed to serine, and the phenylalanines substituted by alanines (KSAA) to mutants with phenylalanines or tyrosines present in the -1 / -2 position from the COOH terminus (KSFF, KSFY, KSYF, KSYY) showed that terminal phenylalanine/tyrosine residues suppress the RSQQE determinant (Fig. 6, lines 10-14) .
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