Selected article for: "class ii and MHC class ii"
Title: Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains
  • Document date: 1991_4_1
    • ID: 6acjgug3_2
    Snippet: The cytokine TNF-a has been postulated to have a central role in augmenting inflammatory demyelination and intracerebral immune responses. TNF-a has a diverse range of functions in the CNS, which include induction ofclass I MHC antigens on astrocytes (17, 18) ; induction of ICAM-1 on human fetal astrocytes (19) ; upregulation of class II MHC antigens induced by IFN-y and/or virus on astrorytes (6-8); stimulation of IIr6 secretion by astrocytes (1.....
    Document: The cytokine TNF-a has been postulated to have a central role in augmenting inflammatory demyelination and intracerebral immune responses. TNF-a has a diverse range of functions in the CNS, which include induction ofclass I MHC antigens on astrocytes (17, 18) ; induction of ICAM-1 on human fetal astrocytes (19) ; upregulation of class II MHC antigens induced by IFN-y and/or virus on astrorytes (6-8); stimulation of IIr6 secretion by astrocytes (14, 15) ; proliferation of adult astrorytes (20) ; myelin damage (21) ; and lysis of oligodendrocytes (12) . Astrocytes also express high affinity receptors for TNF-a (7), as well as produce TNF-a, which may represent an autocrine pathway of stimulation for these cells.

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