Author: Uversky, Vladimir N
Title: The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins Document date: 2013_4_1
ID: 63gh2tg4_6
Snippet: Glutamic acid is second of the most common disorder-promoting residues. Figure 1B and Table 1 represent the result of a statistical analysis of the amino acid compositions of proteins in four standard data sets (DisProt, 49 UniProt, 51 PDB Select 25 50 and surface residues 48 ) and shows that the glutamic acid content in these data sets is 9.89 ± 0.61%, 6.67 ± 0.04%, 6.65 ± 0.07% and 8.70 ± 0.17%, respectively (cprofiler.org/help. html). 48 I.....
Document: Glutamic acid is second of the most common disorder-promoting residues. Figure 1B and Table 1 represent the result of a statistical analysis of the amino acid compositions of proteins in four standard data sets (DisProt, 49 UniProt, 51 PDB Select 25 50 and surface residues 48 ) and shows that the glutamic acid content in these data sets is 9.89 ± 0.61%, 6.67 ± 0.04%, 6.65 ± 0.07% and 8.70 ± 0.17%, respectively (cprofiler.org/help. html). 48 In other words, IDPs/IDPRs contain 1.48-and 1.49times more glutamic acid residues than the average natural proteins from UniProt or ordered proteins from PDB, respectively. Furthermore, the glutamic acid content in IDPs/IDPRs is 1.14times higher than that on the surfaces of ordered proteins.
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