Author: Beigel, John H.; Tebas, Pablo; Elie-Turenne, Marie-Carmelle; Bajwa, Ednan; Bell, Todd E.; Cairns, Charles B.; Shoham, Shmuel; Deville, Jaime G.; Feucht, Eric; Feinberg, Judith; Luke, Thomas; Raviprakash, Kanakatte; Danko, Janine; O’Neil, Dorothy; Metcalf, Julia A.; King, Karen; Burgess, Timothy H.; Aga, Evgenia; Lane, H. Clifford; Hughes, Michael D.; Davey, Richard T.
Title: A Randomized Study of Immune Plasma for the Treatment of Severe Influenza Document date: 2017_5_15
ID: 2g22oqf2_7
Snippet: Participants were randomized by an online randomization system in a 1:1 ratio to receive either 2 units of ABO-matched plasma (volume range: 225-350 ml/unit or 8 ml/kg pediatric equivalent) on Study Day 0 in addition to standard care versus standard care alone. Standard care could vary depending upon the clinical needs of the patient but all participants were required to receive a neuraminidase inhibitor as part of their treatment. A computer gen.....
Document: Participants were randomized by an online randomization system in a 1:1 ratio to receive either 2 units of ABO-matched plasma (volume range: 225-350 ml/unit or 8 ml/kg pediatric equivalent) on Study Day 0 in addition to standard care versus standard care alone. Standard care could vary depending upon the clinical needs of the patient but all participants were required to receive a neuraminidase inhibitor as part of their treatment. A computer generated central randomization scheme was used, with stratification by age group and pregnancy status (<2 years, ≥2 years to <8 years, ≥8 years to <18 years and not pregnant, ≥ 18 years and not pregnant, and pregnant). Randomization was not stratified by site nor measures of disease severity. The study was not blinded.
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