Author: Munday, Diane C.; Emmott, Edward; Surtees, Rebecca; Lardeau, Charles-Hugues; Wu, Weining; Duprex, W. Paul; Dove, Brian K.; Barr, John N.; Hiscox, Julian A.
Title: Quantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus Document date: 2010_7_20
ID: 2zhaknbi_63
Snippet: Disruption to Subnuclear Structures-The nucleus contains several subnuclear structures with defined functions. These structures are believed to form around hub proteins and are composed of protein-protein and protein-nucleic acid interactions (64, 105) . In this study, the abundance of proteins associated with the nucleolus and ND10s were altered in HRSV-infected cells. Both the nucleolus and ND10s are dynamic structures whose proteins are in con.....
Document: Disruption to Subnuclear Structures-The nucleus contains several subnuclear structures with defined functions. These structures are believed to form around hub proteins and are composed of protein-protein and protein-nucleic acid interactions (64, 105) . In this study, the abundance of proteins associated with the nucleolus and ND10s were altered in HRSV-infected cells. Both the nucleolus and ND10s are dynamic structures whose proteins are in constant interchange with the nucleoplasm whose specific composition can depend on the metabolic state of the cell, and ND10s are associated with antiviral defense (63) .
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