Author: Fathi, Anahita; Dahlke, Christine; Addo, Marylyn M.
Title: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens Document date: 2019_9_5
ID: 4cia91cq_15
Snippet: All vaccinations are given intramuscular at a dose of 2x10^7 PFU and as a single-shot, unless otherwise noted. V920 trial numbers adapted from Monath et al. PACTR = Pan African Clinical Trial Registry. incidence, which was more pronounced in the lower dose cohort (here: 2 × 10 7 PFU vs. 1 × 10 8 PFU). 35 The first emerging data from a small subset of 90 surveyed individuals vaccinated during the current EVD outbreak in the DRC seem to mirror th.....
Document: All vaccinations are given intramuscular at a dose of 2x10^7 PFU and as a single-shot, unless otherwise noted. V920 trial numbers adapted from Monath et al. PACTR = Pan African Clinical Trial Registry. incidence, which was more pronounced in the lower dose cohort (here: 2 × 10 7 PFU vs. 1 × 10 8 PFU). 35 The first emerging data from a small subset of 90 surveyed individuals vaccinated during the current EVD outbreak in the DRC seem to mirror the safety assessment obtained in these clinical trials, and while adverse events were frequent, arthralgia and rash were reported in only 7% and 5%, respectively. 42 Importantly, vaccine satisfaction was reported to be high, which is a very encouraging finding, as misconceptions about the vaccine and EVD constitute a serious challenge for health-care workers to administer vaccinations and care in the current outbreak setting.
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