Selected article for: "acute phase and adaptive immune protection"
Author: Fathi, Anahita; Dahlke, Christine; Addo, Marylyn M.
Title: Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens
  • Document date: 2019_9_5
    • ID: 4cia91cq_23
    Snippet: First insights into possible correlates of protection have been provided by assessing immune responses of survivor and fatal cases from EBOV-infected individuals following the West African EVD epidemic. One study demonstrated that fatal cases were associated with an increased expression of the exhaustion markers CTLA-4 and PD-1 on CD4 + and CD8 + T cells. 64 A transcriptomic analysis of blood RNA from EBOV-infected patients showed elevated expres.....
    Document: First insights into possible correlates of protection have been provided by assessing immune responses of survivor and fatal cases from EBOV-infected individuals following the West African EVD epidemic. One study demonstrated that fatal cases were associated with an increased expression of the exhaustion markers CTLA-4 and PD-1 on CD4 + and CD8 + T cells. 64 A transcriptomic analysis of blood RNA from EBOV-infected patients showed elevated expression levels of genes associated with interferons and acute phase signaling pathways. 65 Lower levels of inflammation correlated with virus clearance and robust EBOV-specific T-cell responses. Although these novel data provide insight into innate and adaptive immune responses, their contribution to protection in humans is still not defined. Notably, correlates of protection may differ between natural EVD infection and vaccineinduced immune responses.

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