Author: Lew, Qiao Jing; Chu, Kai Ling; Lee, Jialing; Koh, Poh Ling; Rajasegaran, Vikneswari; Teo, Jin Yuan; Chao, Sheng-Hao
Title: PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription Document date: 2010_9_4
ID: 174q2pjw_32
Snippet: In this study, we investigate the molecular mechanism to elucidate the distinct functions between the inactive XBP-1U and active XBP-1S. Both isoforms have an identical N-terminus and an isoform-specific C-terminal region (Figure 2A ). We identify PCAF as a novel XBP-1S binding protein and demonstrate the biological importance of PCAF in regulating the XBP-1S-mediated cellular and viral transcription. PCAF binds to XBP-1S through the interaction .....
Document: In this study, we investigate the molecular mechanism to elucidate the distinct functions between the inactive XBP-1U and active XBP-1S. Both isoforms have an identical N-terminus and an isoform-specific C-terminal region (Figure 2A ). We identify PCAF as a novel XBP-1S binding protein and demonstrate the biological importance of PCAF in regulating the XBP-1S-mediated cellular and viral transcription. PCAF binds to XBP-1S through the interaction with the XBP-1S-specific C-terminal domain but fails to associate with the full-length XBP-1U or the XBP-1U-specific C-terminus (Figures 1 and 2) , providing an explanation for the transactivating ability of XBP-1S on gene expression.
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