Age-related rhesus macaque models of COVID-19

Yu, Pin; Qi, Feifei; Xu, Yanfeng; Li, Fengdi; Liu, Peipei; Liu, Jiayi; Bao, Linlin; Deng, Wei; Gao, Hong; Xiang, Zhiguang; Xiao, Chong; Lv, Qi; Gong, Shuran; Liu, Jiangning; Song, Zhiqi; Qu, Yajin; Xue, Jing; Wei, Qiang; Liu, Mingya; Wang, Guanpeng; Wang, Shunyi; Yu, Haisheng; Liu, Xing; Huang, Baoying; Wang, Wenling; Zhao, Li; Wang, Huijuan; Ye, Fei; Zhou, Weimin; Zhen, Wei; Han, Jun; Wu, Guizhen; Jin, Qi; Wang, Jianwei; Tan, Wenjie; Qin, Chuan

We report nonhuman primate models for COVID-19 infected with SARS-CoV-2 (HB-01). Three rhesus macaques (divided into younger group, YG) between 3 and 5 years old and two rhesus macaques (divided into elder group, EG) about 15 years old were inoculated with 1 × 10 6 TCID 50 of SARS-CoV-2 through intratracheal route. Clinical signs including weight loss, fever, asthenia and lethality were recorded in Table 1 , the weight was decreased obviously from 3 dpi in all the monkeys except one young monkey but without significant change of body temperature during the entire observation. Clinical signs were transient and lasted for a few days. Nasal, throat, and anal swabs were obtained from animals on 0, 3, 5, 7, 9, 11 , and 14 days post-inoculation (dpi).