Author: Ivanova, Elena; Berger, Audrey; Scherrer, Anne; Alkalaeva, Elena; Strub, Katharina
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits Document date: 2015_3_11
ID: 64cnoqpi_71
Snippet: In cells, detectable effects on translation were observed for mRNAs initiating translation de novo. This may be because mRNAs in polysomes can adopt a closed-loop conformation due to the interaction of the scaffold factor eIFG4 with the poly(A)-binding protein (44) . Due to facilitated ribosome recycling within these structures, translation might be less sensitive to 40S inactivation by SRP9/14. Following stress and certain viral infections, poly.....
Document: In cells, detectable effects on translation were observed for mRNAs initiating translation de novo. This may be because mRNAs in polysomes can adopt a closed-loop conformation due to the interaction of the scaffold factor eIFG4 with the poly(A)-binding protein (44) . Due to facilitated ribosome recycling within these structures, translation might be less sensitive to 40S inactivation by SRP9/14. Following stress and certain viral infections, polysomes are disassembled and translation undergoes major reprogramming with certain mRNAs engaging de novo in protein synthesis (45, 46) increasing the sensitivity of their translation to 40S inactivation.
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