Plasma citrulline, arginine, nitric oxide, and blood ammonia levels in neonatal calves with acute diarrhea

Gultekin, Mehmet; Voyvoda, Huseyin; Ural, Kerem; Erdogan, Hasan; Balikci, Canberk; Gultekin, Gamze

Further demographic information and the statistical evaluation of laboratory findings in control and diarrheic calves are summarized in Table 2 . Overall, calves with acute diarrhea had higher WBC, K, AST, creatinine and urea, NO and blood ammonia, and lower pH, HCO 3 , BE, total protein, CIT, and ARG values than healthy control calves (Table 2) , and the differences in plasma CIT and its related metabolites remained important after adjusting for age. There was a significant effect of time on plasma CIT (P = .03), ARG (P < .001), NO (P = .01), and blood ammonia concentrations (P = .008) in the healthy control group during the neonatal period (Supporting information Figure S1 ). significantly lower in the infectious diarrhea ( Figure 1B ), in FS 3 ( Figure 2B ), severe dehydration ( Figure 3B) , and SIRS-positive subgroups ( Figure 4B ) than in the healthy control group. In addition, plasma ARG concentrations were significantly lower in the severe dehydrated subgroup than in the mild dehydration subgroup (P = .03) and in the SIRS-positive subgroup than in the SIRS-negative subgroup (P < .001).