Selected article for: "cell cross reactivity and cross reactivity"
Author: Fausther-Bovendo, Hugues; Kobinger, Gary P
Title: Pre-existing immunity against Ad vectors: Humoral, cellular, and innate response, what's important?
  • Document date: 2014_11_1
    • ID: 3894l9qi_9
    Snippet: Ad specific T cell inhibition of vector efficacy is important due to their cross-reactivity. Indeed, unlike nAbs, Ad specific T cells are able to recognize a broad range of HAd from different subgroups (Fig. 1B) . Several groups have shown that human CD4 and CD8 T cells predominantly recognize conserved epitopes in the adenovirus hexon, especially in the C-terminal region, [27] [28] [29] [30] [31] with a limited number of T cells targeting the fi.....
    Document: Ad specific T cell inhibition of vector efficacy is important due to their cross-reactivity. Indeed, unlike nAbs, Ad specific T cells are able to recognize a broad range of HAd from different subgroups (Fig. 1B) . Several groups have shown that human CD4 and CD8 T cells predominantly recognize conserved epitopes in the adenovirus hexon, especially in the C-terminal region, [27] [28] [29] [30] [31] with a limited number of T cells targeting the fiber and penton region. 29, 30 In addition to being widely cross-reactive, Ad specific T cells are detected in the great majority of tested individuals. Ad5 reactive CD4 or CD8 T cells were detected in 80% to 100% of subjects in Amsterdam, Netherlands 30, 32 and in all subjects in Philadelphia, USA. 29, 33, 34 It is worth noting that these individuals were not screened for pre-existing Ad immunity using nAbs.

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