Author: Beigel, John H.; Tebas, Pablo; Elie-Turenne, Marie-Carmelle; Bajwa, Ednan; Bell, Todd E.; Cairns, Charles B.; Shoham, Shmuel; Deville, Jaime G.; Feucht, Eric; Feinberg, Judith; Luke, Thomas; Raviprakash, Kanakatte; Danko, Janine; O’Neil, Dorothy; Metcalf, Julia A.; King, Karen; Burgess, Timothy H.; Aga, Evgenia; Lane, H. Clifford; Hughes, Michael D.; Davey, Richard T.
Title: A Randomized Study of Immune Plasma for the Treatment of Severe Influenza Document date: 2017_5_15
ID: 2g22oqf2_40
Snippet: At baseline, there were some differences in oxygen dependency, rates of mechanical ventilation, and APACHE scores suggesting that the standard care arm may have had participants presenting with more severe disease. Due to the association of age and pregnancy with outcomes in H1N1 influenza, these were chosen as the primary stratification categories for randomization. With the limited sample size, we were concerned that additional stratification c.....
Document: At baseline, there were some differences in oxygen dependency, rates of mechanical ventilation, and APACHE scores suggesting that the standard care arm may have had participants presenting with more severe disease. Due to the association of age and pregnancy with outcomes in H1N1 influenza, these were chosen as the primary stratification categories for randomization. With the limited sample size, we were concerned that additional stratification could have led to incomplete filling of blocks (over-stratification), and subsequent imbalances. The differences in the severity of illness likely also accounts for the higher viral burden in nasal and oropharyngeal swabs at baseline in the standard care arm.
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