Author: Zhengqiao Zhao; Bahrad A. Sokhansanj; Gail L. Rosen
Title: Characterizing geographical and temporal dynamics of novel coronavirus SARS-CoV-2 using informative subtype markers Document date: 2020_4_9
ID: 9sk11214_10
Snippet: The majority of the remaining sites (9/16) were found in the ORF1ab polyprotein, which encodes a 229 polyprotein replicase complex that is cleaved to form nonstructural proteins that are used as RNA 230 polymerase (i.e., synthesis) machinery [16] . One site is located in the reading frame encoding the S spike 231 glycoprotein, which is responsible for viral entry and antigenicity, and thus represents an important target for 232 understanding the .....
Document: The majority of the remaining sites (9/16) were found in the ORF1ab polyprotein, which encodes a 229 polyprotein replicase complex that is cleaved to form nonstructural proteins that are used as RNA 230 polymerase (i.e., synthesis) machinery [16] . One site is located in the reading frame encoding the S spike 231 glycoprotein, which is responsible for viral entry and antigenicity, and thus represents an important target for 232 understanding the immune response, identifying antiviral therapeutics, and vaccine design [22, 34] .
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