A review of vaccine development and research for industry animals in Korea

Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok

The resulting product is combined with proper adjuvant and used as the subunit recombination vaccine. Such vaccine has a benefit due to its inability to replicate in the host, and well tolerated due to the addition of a good purification step. Given the broad range of availability for this approach, it is more feasible to produce subunit vaccine for various types of pathogens. The immunogen in subunit vaccines may be purified proteins, peptides, or polysaccharide. Since these antigens alone have weak immunogenicity, immunity established by the vaccine may be enhanced by administration with a potent adjuvant or through a well-defined delivery system. In general, multiple doses of such vaccine are needed to attain satisfactory immunological responses with most subunit vaccines. In certain cases, administration of vaccine with appropriate adjuvant enables induction of cellmediated immunity, useful for preventing diseases caused by bacteria that grow intracellularly.