Author: Ivanova, Elena; Berger, Audrey; Scherrer, Anne; Alkalaeva, Elena; Strub, Katharina
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits Document date: 2015_3_11
ID: 64cnoqpi_2
Snippet: The canonical pathway for translation initiation proceeds through sequential formation of several initiation complexes (3) . Ternary complex and the initiation factors bind to the 40S ribosomal subunit yielding the 43S preinitiation complex, which is then loaded onto the 5 -proximal region of an mRNA and scans for the initiation codon. Once the initiation codon is positioned at the P-site, the 48S initiation complex is assembled. The joining of t.....
Document: The canonical pathway for translation initiation proceeds through sequential formation of several initiation complexes (3) . Ternary complex and the initiation factors bind to the 40S ribosomal subunit yielding the 43S preinitiation complex, which is then loaded onto the 5 -proximal region of an mRNA and scans for the initiation codon. Once the initiation codon is positioned at the P-site, the 48S initiation complex is assembled. The joining of the 60S ribosomal subunit leads to formation of the 80S initiation complex, which then proceeds to elongation cycles.
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