Author: Gershoni, Jonathan M.
Title: B-cell restriction – an alternative piece to the puzzle Document date: 2019_4_23
ID: 5ibowkyq_20
Snippet: One means to better focus the response towards select neutralizing epitopes would be to remove all otherwise distracting antigens. Subunit vaccines are the first step towards this goal. Instead of vaccinating with intact Pertussis bacterium (some 2000 proteins), a-cellular vaccines present to our immune system a handful of only the most relevant Pertussis antigens. 49, 50 Similarly, Hepatitis B surface antigen is a good example of a successful su.....
Document: One means to better focus the response towards select neutralizing epitopes would be to remove all otherwise distracting antigens. Subunit vaccines are the first step towards this goal. Instead of vaccinating with intact Pertussis bacterium (some 2000 proteins), a-cellular vaccines present to our immune system a handful of only the most relevant Pertussis antigens. 49, 50 Similarly, Hepatitis B surface antigen is a good example of a successful subunit vaccine. [51] [52] [53] Recently, the Human Papilloma Virus subunit vaccine illustrates how the use of recombinant L1 capsid protein can reduce the occurrence of cervical cancer. [54] [55] [56] [57] If one is able to dissect out the neutralizing epitope exclusively, this could lead to the ultimate form of targeted vaccination, i.e., epitope-based vaccines. 58
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