Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments

Jartti, Tuomas; Smits, Hermelijn H.; Bønnelykke, Klaus; Bircan, Ozlem; Elenius, Varpu; Konradsen, Jon R.; Maggina, Paraskevi; Makrinioti, Heidi; Stokholm, Jakob; Hedlin, Gunilla; Papadopoulos, Nikolaos; Ruszczynski, Marek; Ryczaj, Klaudia; Schaub, Bianca; Schwarze, Jürgen; Skevaki, Chrysanthi; Stenberg-Hammar, Katarina; Feleszko, Wojciech

and to the initiation of asthma controller medication within the following 5 years by 30%-40% in first-time wheezing children with RV etiology. These results point out that early systemic anti-inflammatory control targeting the pre-existing and/or virus-induced airway inflammatory response could significantly affect the natural course of asthma. [74] [75] [76] [77] Interestingly, all wheezing children with high RV genome load treated with placebo developed a new physician-confirmed wheezing episode within 100 days and initiation of asthma control medication within 14 months. 76, 77 In conclusion, according to our hypothesis regarding the various entities of bronchiolitis, we emphasize that effective treatment of bronchiolitis should be administered on a more personalized base than currently in practice and include various viral etiological factors.