Clinical Features and Radiological Findings of Adenovirus Pneumonia Associated with Progression to Acute Respiratory Distress Syndrome: A Single Center Study in 19 Adult Patients

Cha, Min Jae; Chung, Myung Jin; Lee, Kyung Soo; Kim, Tae Jung; Kim, Tae Sung; Chong, Semin; Han, Jungho

Detailed patient characteristics are shown in Table 1 . Among the 19 patients with adenovirus pneumonia, nine were immunocompromised due to underlying comorbid conditions, such as acute myeloid leukemia (n = 4), non-Hodgkin's lymphoma (n = 1), multiple myeloma (n = 1), lung adenocarcinoma (n = 1), history of liver transplantation for hepatocellular carcinoma (n = 1), and Korean J Radiol 17 (6) kjronline.org diabetes mellitus in conjunction with chronic obstructive pulmonary disease and ischemic cardiomyopathy (n = 1). In contrast, 10 patients were immunocompetent without underlying disease. Most patients had upper respiratory symptoms such as dyspnea, cough, sputum, fever, and chills, as shown in Table 1 . Twelve of 19 patients (63%) subsequently progressed to ARDS, six (32%) of whom eventually died. The average time of progression from commencement of symptoms or signs to ARDS was 9.6 days, indicating relatively rapid deterioration. Fifteen patients received antiviral therapy, including ganciclovir (n = 1), ribavirin (n = 3), or cidofovir (n = 11).