Clinical Features and Radiological Findings of Adenovirus Pneumonia Associated with Progression to Acute Respiratory Distress Syndrome: A Single Center Study in 19 Adult Patients

Cha, Min Jae; Chung, Myung Jin; Lee, Kyung Soo; Kim, Tae Jung; Kim, Tae Sung; Chong, Semin; Han, Jungho

We identified 19 adult patients (14 males and 5 females; median age, 38 years) who were diagnosed with adenovirus pneumonia between March 2003 and April 2015 in a single tertiary-referral hospital. All patients underwent Gram stains, bacterial and fungal cultures of blood and urine. Sputum was stained and cultured for bacteria, mycobacteria, and fungi. Specimens from patients who underwent bronchoscopy with the collection of bronchoalveolar lavage (BAL) fluid or lung biopsy, as well as those who underwent surgical biopsy, were stained and cultured for bacteria, mycobacteria, and fungi. In addition, polymerase chain reaction (PCR) analysis for BAL specimens and nasal or throat swabs were performed to detect viral organisms. Patients in whom other infectious organisms were identified in the sputum, blood, urine, nasal and throat swabs, BAL fluid, or lung specimen within four weeks of adenovirus identification were regarded to have a concurrent infection and were excluded from this study. Finally, 19 patients confirmed to have only adenovirus pneumonia were included in this study; these patients included the five patients whose imaging features were published in our previous study (10) .