Selected article for: "important role and inflammatory cytokine"
Author: Roh, Da Eun; Park, Sook-Hyun; Choi, Hee Joung; Kim, Yeo Hyang
Title: Comparison of cytokine expression profiles in infants with a rhinovirus induced lower respiratory tract infection with or without wheezing: a comparison with respiratory syncytial virus
  • Document date: 2017_9_21
    • ID: 6jd1jeof_32
    Snippet: IFN-γ is a pro-inflammatory and immune-regulatory cytokine related to nonspecific defense mechanism. It is secreted from neutrophils at the site of the viral infection, and inhibits viral replication 11) . Infants hospi talized with severe RSV disease had a reduction in IFN-γ levels in nasopharyngeal aspirates and a decreased expression of IFN-γ by peripheral blood mononuclear cells 16, 17) . In addition, IFN-γ can induce airway hyper-respons.....
    Document: IFN-γ is a pro-inflammatory and immune-regulatory cytokine related to nonspecific defense mechanism. It is secreted from neutrophils at the site of the viral infection, and inhibits viral replication 11) . Infants hospi talized with severe RSV disease had a reduction in IFN-γ levels in nasopharyngeal aspirates and a decreased expression of IFN-γ by peripheral blood mononuclear cells 16, 17) . In addition, IFN-γ can induce airway hyper-responsiveness and tends to aid in the develop ment of wheezing 18) . A previous study also demonstrated that the expression levels of IFN-γ were higher at the time of RV infection and played an important role in RV-induced early wheezing 18) . The present study showed that IFN-γ levels had not only RSV induced LRTI with or without wheezing but also RV induced LRTI with wheezing like the previous studies. IFN-γ showed a significant rela tion to wheezing in RV-induced LRTI.

    Search related documents:
    Co phrase search for related documents
    • airway induce and important role: 1
    • blood mononuclear and decreased expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • blood mononuclear and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • blood mononuclear and IFN γ decreased expression: 1, 2
    • blood mononuclear and IFN γ expression level: 1, 2
    • blood mononuclear and IFN γ level: 1, 2, 3
    • blood mononuclear and important role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • blood mononuclear and nasopharyngeal aspirate: 1
    • blood mononuclear cell and expression level: 1, 2
    • blood mononuclear cell and important role: 1, 2, 3, 4, 5
    • decreased expression and defense mechanism: 1, 2
    • decreased expression and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • decreased expression and IFN γ decreased expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • decreased expression and IFN γ expression level: 1
    • decreased expression and IFN γ level: 1, 2, 3, 4, 5
    • decreased expression and important role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • defense mechanism and expression level: 1
    • defense mechanism and important role: 1, 2, 3, 4, 5, 6, 7
    • expression level and IFN γ expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12