Title: Compartmentation of the Golgi complex: brefeldin-A distinguishes trans- Golgi cisternae from the trans-Golgi network Document date: 1990_9_1
ID: 47k2yobm_36
Snippet: Another possibility is that BFA acts on the Golgi complex and interferes with the mechanism whereby Golgi compartmentation is maintained (9, 28, 29) . This model would re-quire that cis-, medial and trans-Golgi cisternae be related by a common compartmentation machinery that would not apply to the TGN. Whatever mechanism BFA uses to block ER export and disrupt Golgi organization, the apparent insensitivity of the TGN to BFA action highlights a fu.....
Document: Another possibility is that BFA acts on the Golgi complex and interferes with the mechanism whereby Golgi compartmentation is maintained (9, 28, 29) . This model would re-quire that cis-, medial and trans-Golgi cisternae be related by a common compartmentation machinery that would not apply to the TGN. Whatever mechanism BFA uses to block ER export and disrupt Golgi organization, the apparent insensitivity of the TGN to BFA action highlights a fundamental difference between this compartment and more proximal Golgi cisternae.
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