Selected article for: "acute respiratory syndrome and positive strand RNA virus"
Author: Lee, Na-Ra; Kwon, Hyun-Mi; Park, Kkothanahreum; Oh, Sangtaek; Jeong, Yong-Joo; Kim, Dong-Eun
Title: Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13
  • Document date: 2010_7_29
    • ID: 1k99yv4i_1
    Snippet: Severe acute respiratory syndrome (SARS) that claimed almost 800 deaths in southern China within a few months between 2002 and 2003 was caused by a novel coronavirus, SARS coronavirus (SCV) (1). SARS continues to be a serious concern as long as there is no vaccine or effective drug. SCV is a single-stranded (ss) RNA positive-strand virus with a genome of 29 727 nt (2, 3) . A single 21.2-kb replicase gene at the 5 0 -end region of the SCV genome i.....
    Document: Severe acute respiratory syndrome (SARS) that claimed almost 800 deaths in southern China within a few months between 2002 and 2003 was caused by a novel coronavirus, SARS coronavirus (SCV) (1). SARS continues to be a serious concern as long as there is no vaccine or effective drug. SCV is a single-stranded (ss) RNA positive-strand virus with a genome of 29 727 nt (2, 3) . A single 21.2-kb replicase gene at the 5 0 -end region of the SCV genome is translated into two large replicative polyproteins, pp1ab ($790 kDa) and pp1a ($490 kDa), which is generated with and without ribosomal frameshifting (À1), respectively (4, 5) . These two translational products are subsequently processed by the viral main protease termed M pro or 3CL pro , generating a number of non-structural proteins (nsPs). These nsPs include the RNA-dependent RNA polymerase (nsP12) and the NTPase/helicase (nsP13), which primarily constitute the membrane-bound viral replicase complex (6, 7) . The viral replicase synthesizes the entire viral genome (replication) as well as eight subgenomic mRNAs (transcription) (8, 9) .

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