Selected article for: "cell surface and ligand receptor"
Title: The v-sis oncoprotein loses transforming activity when targeted to the early Golgi complex
  • Document date: 1994_12_2
    • ID: 2otgb2w8_47
    Snippet: Suramin is a polysulfonated naphthylurea derivative reported to inhibit PDGF mitogenic activity and to revert the v-sis transformed phenotype (Betsholtz et al., 1986) . It is postulated to exert this effect by disruption of ligand-receptor interactions that occur on the cell surface. This mechanism of action is supported by the ability of suramin to reduce the level of tyrosine-phosphorylated cell surface PDGF receptors, while having no effect on.....
    Document: Suramin is a polysulfonated naphthylurea derivative reported to inhibit PDGF mitogenic activity and to revert the v-sis transformed phenotype (Betsholtz et al., 1986) . It is postulated to exert this effect by disruption of ligand-receptor interactions that occur on the cell surface. This mechanism of action is supported by the ability of suramin to reduce the level of tyrosine-phosphorylated cell surface PDGF receptors, while having no effect on the levels of tyrosine phosphorylation of the intracellular, immature forms of the receptors (Fleming et al., 1989) . Since suramin has been shown to accumulate intraceUularly (Hawking, 1978; La-Rocca et al., 1990) , it may also be possible for it to interfere with intracellular interactions between receptor and ligand (Huang and Huang, 1988) .

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